In vitro effects of febrifugine on Schistosoma mansoni adult worms

Table 1 Inhibitory effect of febrifugine on the daily egg output of six paired Schistosoma mansoni adult worms within 7 days

Febrifugine concentration (μg/ml)	Mean daily egg output (± standard error)
Febrifugine concentration (μg/ml)	Day 0	Day 1	Day 2	Day 3	Day 4	Day 5	Day 6	Day 7
Experiment 1
0 (control)	30.0 ± 9.9	115.3 ± 16.3	111.2 ± 18.2	52.8 ± 14.3	47.2 ± 17.6	36.5 ± 12.9	7.3 ± 4.2	5.7 ± 3.3
0.05	20.2 ± 5.8	102.2 ± 13.8	81.0 ± 19.8	43.3 ± 3.8	4.8 ± 3.1^a	0.3 ± 0.3^b	0
0.1	19.7 ± 9.2	101.3 ± 16.1	74.5 ± 7.8	35.8 ± 3.0	1.2 ± 0.3^b	0
0.2	24.7 ± 10.5	51.5 ± 17.5	68.8 ± 29.6	18.0 ± 9.1	0.8 ± 0.5^b	0.2 ± 0.2^b	0
0.5	18.3 ± 6.0	85.3 ± 20.3	50.7 ± 15.5	4.5 ± 2.5^b	1.2 ± 0.8^b	0
Experiment 2
0 (control)	26.5 ± 12.6	94.2 ± 18.8	101.2 ± 21.6	98.3 ± 18.9	57.5 ± 14.8	22.0 ± 6.6	8.7 ± 2.4	4.8 ± 1.9
0.005	20.3 ± 6.3	92.0 ± 18.3	69.0 ± 15.1	88.7 ± 29.0	66.2 ± 26.1	13.2 ± 6.1	6.7 ± 2.6	1.7 ± 0.8
0.01	25.3 ± 10.1	86.5 ± 5.9	78.8 ± 15.8	80.0 ± 15.4	48.0 ± 21.3	6.8 ± 5.7	1.7 ± 1.5	0.7 ± 0.4
0.02	16.8 ± 7.2	100.2 ± 28.5	89.5 ± 13.9	84.7 ± 29.8	12.0 ± 5.4^a	1.7 ± 0.9^a	0

Mean daily egg output during the one-day preincubation (day 0) among the control and febrifugine-treated groups was not significantly different in experiment 1 and 2 (Kruskal-Wallis test, P = 0.88 and 0.92 for all comparisons, respectively)
^aP < 0.05
^bP < 0.01, compared with the corresponding control group according to a Mann-Whitney U test

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