Table 3 Effect of food and parasite infection on the oral absorption of N-251 in mice
From: Pharmacokinetic analysis of new synthetic antimalarial N-251
| Conditions | Pharmacokinetic parameters | ||||
|---|---|---|---|---|---|
| Cmax (ng/mL) | Tmax (h) | AUCpo (ng/mL·h) | F | MRTpo (h) | |
| Normal-fasted (control) | 1677.33 ± 811.23 | 2 | 3768.25 | 0.2277 | 2.46 |
| Infected-fasted | 1767.17 ± 1649.75 | 2 | 3273.35 | 0.1978 | 2.45 |
| Normal-fed | 952.50 ± 332.49 | 1.5 | 2282.17 | 0.1379 | 3.01 |